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KMID : 0363420200340040043
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Journal of Korean Oriental Pediatrics
2020 Volume.34 No. 4 p.43 ~ p.58
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A Review of the Experimental Studies on the Modulatory Effect Herbal Medicine on Gut Microbiota
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Ahn Hye-Ri
Song Ji-Hyun
Lee Hye-Lim
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Abstract
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Objectives: The purpose of this study is to analyze the effect of various herbal medicin on gut microbiota.
Methods: Electronic searches were performed using NDSL, OASIS, KISS, KMBASE, K-portal, Pub med, Cochrane, CNKI.
Results: we analyzed 25 experimental studies on the effect of herbal medicine on microbiota. Diabetes, obesity, inflammatory bowel disease have been frequently studied in micobiota-related disease. The most common experimental animal model used in the studies C57BL/7 mouse. Among the studies wherein single herbal medication were used, Gynostemma pentaphyllum was most commonly studies, and different herbal medications were used in the studies wherein complex herbal medications were studied. Next generation sequencing was performed using Illumina MiSeq system, and gut microbiota analysis was performed using QIIME and Ribosomal Database Project (RDP). In most studies, the herbal medicines exerted regulatory effects on gut microbiota and improved the symptoms of the experimental groups.
Conclusions: This review provides basic data on the correlation between korean medicine and gut microbiota, as well as information for the development of korean medicine.
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KEYWORD
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Gut microbiota, Microbiome, Herbal medicine, Korean medicine, Experimental studies, Review
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